Academic Department of Critical Care

Queen Alexandra Hospital, Portsmouth, UK

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All research activity is undertaken by dedicated staff, who have received ICH-GCP training. Activity is regularly monitored by the trials sponsors and the MHRA, who made a routine inspection of PHT in 2011.

The department operates within the clinical governance structure of PHT with regular minuted morbidity and mortality meetings and within the Trust’s risk reporting system. Our department has an exemplary rolling annual audit programme, and all clinical audits are registered with the PHT audit dept.

Patients and family members may be approached by one of our research team to ask if our patient would like to be considered for participation in a study. You will be provided with information and the opportunity to ask questions and take time to consider these discussions. You are under no obligation to do this but we offer this to all our patients where they meet the eligibility criteria for studies that we are involved with. Details of studies we are currently involved with and previous ones are recorded below:

Current research studies

ADRENAL: ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock

Previous studies

OSCAR: High frequency Oscillation vs conventional ventilation in severe hypoxaemic respiratory failure.
TracMan: HTA funded multicentre trial of early vs late tracheostomy on survival and length of stay
Prowess Shock: Commercially sponsored multicentre international study of activated protein C vs placebo in early stage septic shock, plus proteomics sub study
EASE: environmental monitoring of airborne samples HPA run
European Surgical Outcomes Study: UKCLRN funded point prevalence study
FIRE: Fungal Infection Risk Evaluation - UKCLRN funded
iCanUK: Intensive care follow up identification study
SwiFT: Swine Flu Surveillance 2009/10 UKCLRN funded
USII: Surveillance of unidentified pathogens for the HPA
CALORIES: Early enteral vs parenteral nutrition in critical illness. UKCLRN funded
VANISH: Vasopressin vs Noradrenaline as Initial therapy in septic shock.
FIRST: Faecal Incontinence reassessment study
LeoPARDS: An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis